Nkx2-5 Regulates Tdgf1 (Cripto) Early During Cardiac Development
نویسندگان
چکیده
منابع مشابه
Nkx2-5 transcription in heart development
The heart is the first organ to form in mammals. Cardiogenic lineages originate from paired regions of anterior lateral mesoderm, the cardiac crescent, soon after gastrulation and develop into parallel cardiac primordia that fuse to form the primitive heart tube along the ventral midline of the embryo. Subsequent events of looping, chamber maturation and alignment with the vasculature give rise...
متن کاملControl of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.
The homeobox gene Nkx2-5 is the earliest known marker of the cardiac lineage in vertebrate embryos. Nkx2-5 expression is first detected in mesodermal cells specified to form heart at embryonic day 7.5 in the mouse and expression is maintained throughout the developing and adult heart. In addition to the heart, Nkx2-5 is transiently expressed in the developing pharynx, thyroid and stomach. To in...
متن کاملNanog regulates proliferation during early fish development.
Nanog is involved in controlling pluripotency and differentiation of stem cells in vitro. However, its function in vivo has been studied only in mouse embryos and various reports suggest that Nanog may not be required for the regulation of differentiation. To better understand endogenous Nanog function, more animal models should be introduced to complement the murine model. Here, we have identi...
متن کاملComplex SUMO-1 Regulation of Cardiac Transcription Factor Nkx2-5
Reversible post-translational protein modifications such as SUMOylation add complexity to cardiac transcriptional regulation. The homeodomain transcription factor Nkx2-5/Csx is essential for heart specification and morphogenesis. It has been previously suggested that SUMOylation of lysine 51 (K51) of Nkx2-5 is essential for its DNA binding and transcriptional activation. Here, we confirm that S...
متن کاملMembrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development
cripto is the original member of the family of EGF-CFC genes, recently recognized as novel extracellular factors essential for vertebrate development. During the early stages of mouse gastrulation, cripto mRNA is detected in mesodermal cells; later, cripto mRNA is detected only in the truncus arteriosus of the developing heart. Here we describe the in vivo distribution of Cripto protein through...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical & Experimental Cardiology
سال: 2013
ISSN: 2155-9880
DOI: 10.4172/2155-9880.s11-003